Copyright: © 2026 by the authors. Licensee: Pirogov University.
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ORIGINAL RESEARCH

The effect of membrane filtration on the accuracy of quantitative determination of aprepitant in an aqueous medium

Ubushaev SV , Sepp VV , Bakulin KS , Sen OYu
About authors

Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Sandji V Ubushaev
Ostrovityanova str., 1, Moscow, 117997, Russia; moc.liamg@veahsubu.kijdnas

About paper

Author contribution: Ubushaev SV — development of research design, conducting experiments to assess the effects of filtration and composition of the medium, collection and interpretation of spectral data, writing the main text of the manuscript; Sepp VV — scientific guidance of the work, formulation of a working hypothesis, critical analysis of the obtained patterns, editing and approval of the final version of the article; Bakulin KS — participation in the validation of the analytical method, processing of the obtained results, work with equipment and materials, technical verification of data; Sen OYu — concept development, provision of resources, manuscript writing.

Received: 2026-01-21 Accepted: 2026-02-11 Published online: 2026-02-25
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  1. Liu J, Zou M, Piao H, Liu Y, Tang B, Gao Y, Ma N, Cheng G. Characterization and Pharmacokinetic Study of Aprepitant Solid Dispersions with Soluplus®. Molecules. 2015 Jun 19; 20(6): 11345–56. DOI: 10.3390/molecules200611345. PMID: 26102068; PMCID: PMC6272549.
  2. Wu Y, Loper A, Landis E, Hettrick L, Novak L, Lynn K, et al. The role of biopharmaceutics in the development of a clinical nanoparticle formulation of MK-0869: a Beagle dog model predicts improved bioavailability and diminished food effect on absorption in human. Int J Pharm. 2004 Nov 5; 285(1–2): 135–46. DOI: 10.1016/j.ijpharm.2004.08.001. PMID: 15488686.
  3. Nazlı H, Mesut B, Özsoy Y. In Vitro Evaluation of a Solid Supersaturated Self Nanoemulsifying Drug Delivery System (Super-SNEDDS) of Aprepitant for Enhanced Solubility. Pharmaceuticals (Basel). 2021 Oct 27; 14(11): 1089. DOI: 10.3390/ ph14111089. PMID: 34832871; PMCID: PMC8621193.
  4. Völgyi G, Csicsák D, Takács-Novák K. Right filter-selection for phase separation in equilibrium solubility measurement. Eur J Pharm Sci. 2018 Oct 15; 123: 98–105. DOI: 10.1016/j. ejps.2018.06.031. Epub 2018 Jun 30. PMID: 29969669.
  5. Michlig N, Lehotay SJ, Lightfield AR. Comparison of filter membranes in the analysis of 183 veterinary and other drugs by liquid chromatography-tandem mass spectrometry. J Sep Sci. 2024 Feb; 47(3): e2300696. DOI: 10.1002/jssc.202300696. PMID: 38356232.
  6. Tomas MK, Mijatović A, Nevistić MB, Šarkanj B, Babić J, Kovač T. How different microfilters affect the recovery of eleven EU-regulated mycotoxins. Arh Hig Rada Toksikol. 2023 Apr 4; 74(1): 8–15. DOI: 10.2478/aiht-2023-74-3693. PMID: 37014685; PMCID: PMC10231880.
  7. Zheng YH, Carter E, Zou S, Williams CF, Chow AT, Chen H. Using syringe filtration after lab-scale adsorption processes potentially overestimates PFAS adsorption removal efficiency from non-conventional irrigation water. J Environ Qual. 2025 Jan-Feb; 54(1): 20–30. DOI: 10.1002/jeq2.20640. Epub 2024 Oct 16. PMID: 39414564; PMCID: PMC11718135.