Copyright: © 2026 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
REVIEW
Current problems and future prospects of specific measles therapy
About authors
Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, Saint Petersburg, Russia
Correspondence should be addressed: Irina N Lavrentieva
Mira St., 14, St. Petersburg, 197101, Russia; ur.liam@rwal.ruetsap
About paper
Financing: supported by the Ministry of Health of the Russian Federation and devoted to Development of New Preventive and Therapeutic Drugs against Socially Significant Viral Diseases. UDC 578.2.213; State Registration Number 121030200272-6.
Author contribution: Zarubaev VV — literature review, preparation of the manuscript; Lavrentieva IN — preparation of the manuscript.
Received: 2026-01-19
Accepted: 2026-03-07
Published online: 2026-03-23
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Fig. 1. Chebulagic acid (А) and punicalagin (B) inhibit penetration of the measles virus into the cell [22]
Fig. 2. ZF and Zf and a structurally similar small hydrophobic fusion peptide inhibitor (carbobenzoxy [Z]-D-Phe-L-Phe-Gly, FIP) as inhibitors of the measles virus (MeV) fusion (F) protein
Fig. 3. OX-1 and AM-4 are inhibitors of the measles virus (MeV) fusion (F) protein [26]
Fig. 4. Compounds AM-4 and AS-48, an optimized inhibitor of measles virus fusion protein A [30]
Fig. 5. Localization of FIP resistance mutations in MeV F protein [33] (2017)
Fig. 6. Allosteric measles virus polymerase inhibitors
Fig. 7. ERRP-0519 is a measles virus polymerase inhibitor that exhibits pan-morbilliviral activity [39]
Fig. 8. 5’F-5’-deoxyaristeromycin, an inhibitor of measles virus reproduction [46]
Fig. 9. Droserone, a plant-derived naphthoquinone, inhibits the measles virus
(MV) during the early stages of infection [47].
Fig. 10. (22R,23R)-2α,3α,22,23-tetrahydroxy-β-homo-7-oxa-stigmastan-6-one,
brassinosteroid derivative that has demonstrated activity against the measles
virus [48]
Fig. 11. Compound 09167 is a broad-spectrum immunostimulator active against
myxoviruses [49]
